{"id":5418,"date":"2021-07-16T08:24:57","date_gmt":"2021-07-16T08:24:57","guid":{"rendered":"https:\/\/bsn.org.np\/demo\/?p=5418"},"modified":"2021-07-16T08:24:59","modified_gmt":"2021-07-16T08:24:59","slug":"glycolipid-peptide-vaccination-induces-liver-resident-memory-cd8-t-cells-that-protect-against-rodent-malaria","status":"publish","type":"post","link":"https:\/\/bsn.org.np\/index.php\/2021\/07\/16\/glycolipid-peptide-vaccination-induces-liver-resident-memory-cd8-t-cells-that-protect-against-rodent-malaria\/","title":{"rendered":"Glycolipid-Peptide Vaccination Induces Liver-Resident Memory CD8+ T Cells That Protect Against Rodent Malaria"},"content":{"rendered":"\n<p>2020-06-28<\/p>\n\n\n\n<p> The Liver Is An Important Site Of Replication For\u00a0Plasmodium\u00a0Parasites, And Therefore A Key Goal In Vaccination Against Malaria Is To Induce Robust Antiparasitic Immunity In The Liver. Using\u00a0Plasmodium Berghei\u00a0As A Model To Study Malaria In Mice, Holz\u00a0Et Al.\u00a0Have Developed A Glycolipid-Peptide Conjugate Vaccine That Induced Robust T Cell Responses In The Liver And Was Able To Protect Mice When Challenged With\u00a0P. Berghei. Inclusion Of The Glycolipid Adjuvant, \u0391-Galactosylceramide (\u0391-GalCer) That Activates Natural Killer T (NKT) Cells Was Vital To Promote Antiparasitic Immunity In The Liver. The Authors Propose That Agonists That Activate NKT Cells Could Be Useful In Priming Immune Responses In The Liver In The Context Of Malaria And In Other Hepatotropic Diseases.<\/p>\n\n\n\n<p><strong><em>By Aishwarya Thapa\u00a0<\/em><\/strong><\/p>\n\n\n\n<p><strong><em>Executive Member, BSN<\/em><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>2020-06-28 The Liver Is An Important Site Of Replication For\u00a0Plasmodium\u00a0Parasites, And Therefore A Key Goal In Vaccination Against Malaria Is To Induce Robust Antiparasitic Immunity In The Liver. Using\u00a0Plasmodium Berghei\u00a0As A Model To Study Malaria In Mice, Holz\u00a0Et Al.\u00a0Have Developed A Glycolipid-Peptide Conjugate Vaccine That Induced Robust T Cell Responses In The Liver And Was [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[76],"tags":[],"class_list":["post-5418","post","type-post","status-publish","format-standard","hentry","category-news"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bsn.org.np\/index.php\/wp-json\/wp\/v2\/posts\/5418","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bsn.org.np\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bsn.org.np\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bsn.org.np\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bsn.org.np\/index.php\/wp-json\/wp\/v2\/comments?post=5418"}],"version-history":[{"count":0,"href":"https:\/\/bsn.org.np\/index.php\/wp-json\/wp\/v2\/posts\/5418\/revisions"}],"wp:attachment":[{"href":"https:\/\/bsn.org.np\/index.php\/wp-json\/wp\/v2\/media?parent=5418"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bsn.org.np\/index.php\/wp-json\/wp\/v2\/categories?post=5418"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bsn.org.np\/index.php\/wp-json\/wp\/v2\/tags?post=5418"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}