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Quinolone-3-Diarylethers: A New Class of Antimalarial Drug

The goal for developing new antimalarial drugs is to find a molecule that can target multiple stages of the parasite’s life cycle, thus impacting prevention, treatment, and transmission of the disease. The 4(1H)-quinolone-3-diarylethers are selective potent inhibitors of the parasite’s mitochondrial cytochrome bc1 complex. These compounds are highly active against the human malaria parasites Plasmodium falciparum and Plasmodium vivax. They target both the liver and blood stages of



Single-shot malaria treatment on the horizon

Early research on a new malaria drug indicates it could be effective for treating and preventing the devastating disease, says an international team of researchers. The drug, which is now undergoing Phase II clinical trials in humans, inhibits an enzyme essential to the survival of malaria. If successful, the drug could be used as part of a single dose treatment regime, they report in the journal Science Translational Medicine . "Treatments often fail because patients don'



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