Staphylococcus aureus found in and on human body has found to have tissue healing toxin that stimulates tissue regeneration. It is a harmless bacteria that is common in one out of 4 people on mucous membrane of respiratory tract or on their skin. However, it can be pathogenic when it tends to multiply fast especially when an individual has weak immune system after an injury or an infection, leading to skin inflammation and lung infection and in severe case- sepsis.
A study on human immune system and molecular defense mechanism against infections caused by Staphylococcus aureus was done by The Pharmaceutical Chemistry Professor and his team and discovered that tissue damaging toxin from this bacteria have healing properties too which did not damage the cells at all. The bacterial toxin stimulates specific immune cells which produces anti-inflammatory messenger substances that reduce inflammation and enhance tissue healing. It is believed to contribute in future treatments of skin inflammation and chronic wounds.
In a recent study by researchers from University of Jena, Jena University Hospital and Leibniz Institute, Harvard Medical School and University of Naples College, examined effect of toxin on M2 macrophages to study hemolysin that is a bacterial toxin. The M2 macrophages of immune cells ensure that the destroyed bacteria and damaged cellular components are removed in later stages of inflammatory responses and they make sure that regeneration of damaged tissue takes place
Their study reflected that when hemolysin binds to specific receptor proteins on surface of M2 macrophage, it triggers anti-inflammatory messenger substances production in cells and decreases inflammation. These transmitters promote tissue regeneration as observed in an animal model. The anti-inflammatory messenger is composed of maresins, resolvins, protectins which are formed from omega-3 fatty acids.
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